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As a physician, I experimented with Niagen after reading about its effects on animals. During the first week of medication, I started to recall more of my dreams; I also felt more energetic in my three day a week 3 mile runs, which could be placebo since I had no objective measurement. After about a month, I experienced some pressure on my chest and checked my pulse, which became irregular. I'm healthy otherwise, on no medication except for multivitamins and Omega 3. I did an EKG and detected some PAC's (premature atrial contractions), which could be normal for a 62 y/o man. I also experienced cramping at times in my calf muscles during my routine 3 mile runs. The irregular heart beat got worse after less than three months of taking Niagen. I stopped Niagen, and the irregular heart beats resolved after two days. I searched literatures and found an article in the Journal of the American College of Cardiology Jan. 2008 issue, that linked nicotinamide adenosine dinucleotides (NAD) to atrial fibrillation. I don't have any further information about Niagen; so this is just my personal experience.