Bests & Worsts Reviews from Amazon

My doc recommended L-methylfolate after having prescribed a couple of antidepressants. While the antidepressants helped, it only made things bearable - not great. My doc explained that some people do not metabolize folic acid well. Folic acid is normally metabolized into L-methylfolate, which she explained is a precursor of serotonin, endorphins, and dopamine (I THINK I'm remembering that correctly...). If you do not metabolize folic acid efficiently, your body doesn't have the "raw materials" to "manufacture" neurotransmitters. This can be a cause of or an exacerbator of depression, anxiety, and other manifestations. I took 1 mg (1000 micrograms - one capsule) per day at first. After a week, I noticed a definite improvement. I continued for a couple of months, noticing no further change. Then, I increased my dosage to 2 mg per day. After four days, I noticed another improvement. At this dose, I usually feel almost normal again. I am contemplating increasing the dosage to 3 mg per day, but I will wait another couple of months to see my doc again. Clearly, my improvement was caused by taking this supplement. Now, if your body processes folic acid NORMALLY, there is no need to take this supplement. Save yourself the money! But if you suffer from anxiety and/or depression, your doctor has tried a few of the SSRI's and other drugs to increase levels of serotonin in your blood, CERTAINLY give this stuff a try! I recommend you do this with your doctor's knowledge. I also recommend that you do as I am doing -- start with 1 mg/day, and see how you feel after two or three months. If you notice an improvement, notice how long after you start taking this supplement you saw the improvement. If you DO notice an improvement and you feel great, there is no need to take more. If you notice an improvement but you still aren't where you think you SHOULD be, try taking 2 mg/day, again for three months, noticing if and when you feel another boost. After three months, if you felt an improvement with 2 mg/day, then try 3 mg/day, again for three months. When you get to a point where increasing the dose another 1 mg makes no further difference in how you feel, then you have probably found the ultimate dose. As far as this product goes, it CLEARLY is effective and potent (again, ONLY for those who do not metabolize folic acid). I have not tried other brands, but I don't see the need to do so. This price (three bottles all together) is the best I could find. I have ordered it twice through Amazon, and both times delivery has been within a week or less. Bottom line: IF you have the metabolic issue I have spoken of, this product can help, absolutely and unmistakably. Best of luck to you.