Bests & Worsts Reviews from Amazon

***** ***** ***** ***** ***** Update #1: 9-20-2012. Took my first Fisetin supplement today. About 30 minutes in, I experienced a weird feeling I have never felt before. It was like when you want to yawn a lot when you feel really burnt out and tired, and your brain needs more oxygen than it is currently getting, or just as much oxygen as possible. It was like that feeling x10, but at least it only lasted a few minutes, then completely dissipated. Shortly after that my whole brain woke up, and I could think almost as good as I ever could... I distinctly remember this, in fact, because I have been mentally sluggish the past few days, and this was the first time I was back to normal. If this sounds too good to be true, I can't help that, I am just writing what I experienced. Keep in mind that I take other supplements daily but the package was delivered in the afternoon and it was taken hours after the others. ***** ***** ***** ***** ***** Update #2: 9-23-2012. Experienced similar effects as explained above, but to a much less extent, perhaps only 1/5th the feeling I felt the first day, and anywhere from 30min to 1hr 30min after taking 1 Fisetin capsule. The 2nd day was my peak mental clarity. It was actually fairly impressive, I had fleeting moments of the most profound and broad logical applications I think I have ever been able to apply to anything in my entire life. Unfortunately, the past day or so I am back to my recently typical mentally sluggish self. I haven't been able to sleep well at all any of the nights I've taken Fisetin. I have extremely vivid and memorable dreams (not unpleasant, just vivid) and I can't seem to sleep for more than 4-5 hours per night. Again, I'm not sure if any of this is from the Fisetin but it is really the only significant thing that's changed in my diet and routine recently. I'll try to keep updating at regular intervals. ***** ***** ***** ***** ***** Update #3: 9-28-2012. Feeling great. Back to normal nights sleep. I haven't noticed the effect I felt on the first day shortly after taking the caps anymore. And while I've not had any moments of extremely sharp thinking like I had on the 2nd day, I've not noticed anytime when I am thinking slower than usual, since I got better sleep. Tomorrow, I've decided to try Fisetin sublingually as the capsules have powder which looks like it will dissolve easily under the tongue. Will report back in a week or so. ***** ***** ***** ***** ***** Update #4:10-07-2012. Sublingual administration yielded slightly increased effect, however, the increased effect effect only lasted as long as it was dissolving under my tongue (~30min-60min). Not worth it, IMHO, easier to ingest. I can't report on Fisetin anymore, I am still taking Fisetin daily, but I started taking new supplements which more noticeably enhance my mental ability (phenylalanine, tyrosine, choline, + racetams). I'll check back for other experiences, though, I'd especially like to know if anyone else felt what I felt on the 2nd day of taking Fisetin? I am unsure if I will reorder Fisetin. I have felt great, mentally, almost this whole time I've been taking Fisetin. If I go back to feeling mentally sluggish after stopping, then I will reorder, and will be more able to tell if it is the Fisetin. I'll try to remember to update, if that happens. If not, I'll wait for results of actual Fisetin studies done on live humans... ***** ***** ***** ***** ***** Doctor's Best Fisetin is currently the best deal I've found. You get 100mg Fisetin x 30 caps = 3,000mg Fisetin for $11. Swanson gives you the same amount for $17. Regarding legitimacy, I have ordered supplements from both Doctor's Best and Swanson in the past and been happy. Also, both of their Fisetin supplements do NOT come from strawberries, but from the bark/stem of Rhus Succedanea L, not that it would make any difference to your body. Why Fisetine? I heard about Fisetin on a radio show. It was for Purity Product's "37 strawberries", which contains 70mg Fisetin, which to me was the only ingredient even worth buying the supplement for. The list of potential benefits really are miraculous. Purity Products gives you 70mg x 30 caps = 2,100mg Fisetin for $47, and the other ingredients are way too commonplace for that ridiculous price. Hence, why you should always check Amazon for the active ingredient in your medications, so you don't get ripped off. I was really hoping to come here and find a plethora of reviews saying how much Fisetin helped people. I can't find legitimate reviews, anywhere... But I did enough research to convince me to at least try it for $11. I did find some less-than-encouraging information on Wikipedia, though, for example: Fisetin has not been proven to work in vivo in humans, which means these benefits haven't been shown to work live humans (yet?). PLEASE let me and everyone else know if you know of any real studies done that show it work, or if you know of any current studies going on, even. Thanks. When I'm done with this bottle I will use information like that to decide whether or not to re-order it, unless of course I can notice some benefits. ----------------------------------------------------------------------------------- My pros vs. cons list, almost entirely from Wikipedia: Benefits (major) Aside from its effects on aging, various in vitro studies have shown fisetin to exert anti-inflammatory,[4][5] anti-carcinogenic,[6][7] and antiviral[8][9][10][11] effects in different lines of culture cells. Benefit (major), Negative (minor) Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor.[22] This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.[23] As DNA topoisomerase inhibitors, fisetin and other flavonoids may increase risk of infant acute myeloid leukemia, a rare disease.[24]* Benefit (minor) Chinese medicine lists rhus succedanea as having antiinflammatory, antiviral, antibacterial properties, potentially confirming some of the above benefits in vivo (in humans). Anticarcinogenic benefits not being listed here actually speaks to the legitimacy of this source, as homeopathic methods alone should not be able to confirm such benefits. Negative (major) Because in vitro experiments do not or only incompletely mimic fisetin metabolism in the body, they may not accurately reflect the actual effects of fisetin in vivo. During absorption through the small intestine and passage through the liver, fisetin and other flavonoids undergo chemical modifications such that their form in circulating blood is different from that in the original dietary source.[12] Negative (major) Whether such effects can be replicated in humans and other mammals is currently still not entirely clear and remains an issue of scientific research and debate. References: [...] 4. ^ Geraets, Liesbeth; Haegens, Astrid; Brauers, Karen; Haydock, Jane A.; Vernooy, Juanita H.J.; Wouters, Emiel F.M.; Bast, Aalt; Hageman, Geja J. (2009). "Inhibition of LPS-induced pulmonary inflammation by specific flavonoids". Biochemical and Biophysical Research Communications 382 (3): 598-603. doi:10.1016/j.bbrc.2009.03.071. PMID 19292976. 5. ^ Park, Hyo-Hyun; Lee, Soyoung; Son, Hee-Young; Park, Seung-Bin; Kim, Mi-Sun; Choi, Eun-Ju; Singh, Thoudam S. K.; Ha, Jeoung-Hee et al. (2008). "Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells". Archives of Pharmacal Research 31 (10): 1303-11. doi:10.1007/s12272-001-2110-5. PMID 18958421. 6. ^ Lim, D. Y.; Park, J. H. Y. (2009). "Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin". AJP: Gastrointestinal and Liver Physiology 296 (5): G1060-8. doi:10.1152/ajpgi.90490.2008. 7. ^ Khan, N.; Afaq, F.; Syed, D. N.; Mukhtar, H. (2008). "Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells". Carcinogenesis 29 (5): 1049-56. doi:10.1093/carcin/bgn078. PMC 2902387. PMID 18359761.[...] 8. ^ Zandi, K.; Teoh, B. T.; Sam, S. S.; Wong, P. F.; Mustafa, M.; Abubakar, S. (2011). "Antiviral activity of four types of bioflavonoid against dengue virus type-2". Virology Journal 8: 560. doi:10.1186/1743-422X-8-560. PMC 3271998. PMID 22201648. [...]. 9. ^ Lin, Y. J.; Chang, Y. C.; Hsiao, N. W.; Hsieh, J. L.; Wang, C. Y.; Kung, S. H.; Tsai, F. J.; Lan, Y. C. et al. (2012). "Fisetin and rutin as 3C protease inhibitors of enterovirus A71". Journal of Virological Methods 182 (1-2): 93-98. doi:10.1016/j.jviromet.2012.03.020. PMID 22465253. 10. ^ Kang, S. Y.; Kang, J. Y.; Oh, M. J. (2012). "Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses in Vitro". The Journal of Microbiology 50 (2): 293-300. doi:10.1007/s12275-012-2068-7. PMID 22538659. 11. ^ Lyu, S. Y.; Rhim, J. Y.; Park, W. B. (2005). "Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro". Archives of pharmacal research 28 (11): 1293-1301. PMID 16350858. 12. ^ Kroon, P. A.; Clifford, M. N.; Crozier, A.; Day, A. J.; Donovan, J. L.; Manach, C.; Williamson, G. (2004). "How should we assess the effects of exposure to dietary polyphenols in vitro?". The American journal of clinical nutrition 80 (1): 15-21. PMID 15213022. 22. ^ Olaharski, A.J.; Mondrala, S.T.; Eastmond, D.A. (2005). "Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 582 (1-2): 79-86. doi:10.1016/j.mrgentox.2005.01.002. PMID 15781213. 24. ^ Spector, L. G.; Xie, Y; Robison, LL; Heerema, NA; Hilden, JM; Lange, B; Felix, CA; Davies, SM et al. (2005). "Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group". Cancer Epidemiology Biomarkers & Prevention 14 (3): 651-5. doi:10.1158/1055-9965.EPI-04-0602. PMID 15767345. ---------------------------------------------------------------------------------- Also interesting but not necessarily influential is the most likely source of Doctor's Best Fisetin (and all other Fisetin supplements, unless specifically stated otherwise): Most likely source: Asian Wax Tree (Rhus Succedanea L) Other possible source: Asian Smoke Tree (Rhus Cotinus) Price: US $ 10 - 100 / Kilogram Type: Herbal Extract. Variety: Rhus succedanea L. Form: Powder. Part: Bark Extraction. Type: Solvent Extraction. Packaging: Drum. Place of Origin: Shaanxi China (Mainland). Grade: Pharmaceutical and food. Brand Name: Rongsheng. Model Number: 98%,99%. Molecular formula: C15H10O6. Molecular weight: 286.24. Heavy metalsmax: 10PPM. Loss On Drying: ≤1.0%. Pesticides: ≤2PPM. Microbiological plate count: 1000CFU/g. E. Coil: Negative. Salmonella: Negative. Yeast & Mold: 100CFU/g. Appearance: Yellowish, brown powder.