Bests & Worsts Reviews from Amazon

First thing to be aware of with this product is that it was developed for a very specific set of medical conditions - specifically to help with symptoms of gastroparesis and sluggish digestion associated with Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Disorder (MCAD), and POTS. I notice there are some reviews here from buyers who seem to have tried this supplement for other, more general concerns, and to be clear, that is NOT the intended use for this product. I have EDS, MCAD, and POTS with very sluggish digestion and a lot of gastrointestinal pain and constipation. This product definitely helps me with those issues, BUT this stuff is powerful, and I don't know that using it in the absence of these specific conditions is necessarily a good idea. I experienced marked side effects for several weeks starting with just one capsule per day, to the effect of feeling spacey and almost drunk. My body has adjusted slowly over time but my experience tells me that this supplement should not be used casually. I have also had personal correspondence with the creator of this product (who personally suffers from EDS, MCAD, POTS, and gastroparesis) where she has confirmed that the active ingredient whose purpose is to increase bioavailable acetylcholine *does cross the blood-brain barrier*, and that this was intentional because her research suggests that many people with EDS, MCAD, and POTS have autoimmune-induced insufficiency of intrinsic acetylcholine production - meaning that a drug like Mestinon (which blocks reuptake of our own acetylcholine) would not be effective, so that's why she set out to create a product that would be able to cross the blood-brain barrier for the purpose of adding acetylcholine in a way that presumably many of us with EDS, MCAD, and POTS can't do on our own. So in sum... if you suffer from these specific conditions or maybe from idiopathic gastroparesis or vagus nerve damage, this product may really be worth a try for you. But for more general use, I would be very cautious. The bottle does come with a warning to use under the supervision of a doctor.