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The gastro doctor had me on ppi for years for gastritis in my stomach and duodenum and it only made it bearable and gave me all kinds of terrible side effects.I took zinc carnosine for a week at the 150mg dose then quite taking ppi and bumped it up to 300 to 375 for a week then went back down to 225 and I was able to quit the ppi with almost zero withdraw and I'm in less pain now then I have been in years.Every other time I tried to quite ppi it was horrible painfully and I always went back with in ten days but now it has been 5 weeks and its going really good.