Bests & Worsts Reviews from Amazon

I've been using nootropics for decades, since Piracetam and Aniracetam were first available. Noopept is newer, discovered in 1986, it has been available for the past ten years or so in the states. The problem with all racetams is the choline depletion experienced with calcium and sodium ion channel paths. Choline is neither a vitamin or mineral. It is a water-soluble “nutrient” related to the B-Vitamin group. Your brain has a huge appetite for choline. It is critical for the synthesis of the key neurotransmitter acetylcholine. Which your brain uses to maintain clear communication between its billions of neurons. In fact, choline is so vital to cognition and nerve function that, without it, we couldn’t move, think, sleep or remember anything. Using racetams requires choline supplement for *ANY* beneficial effect, unless you eat a lot of eggs, salmon, or nutrition that include choline and inositol. If you use any of the racetam-family of nootropics in your stack, you likely should add a choline supplement. Because the racetams all affect choline and/or acetylcholine use in your brain in some way. Aniracetam – releases more acetylcholine (ACh) Coluracetam – increases choline – ACh conversion through the High Affinity Choline Uptake (HACU) process Noopept – modulates ACh transmission Oxiracetam – enhances choline-acetyltransferase (ChAT) which is used to synthesize acetylcholine Piracetam – potentiates the flow of, and increases the effect of ACh Phenylpiracetam – increases the density of ACh receptors Pramiracetam – increases choline – ACh conversion through the High Affinity Choline Uptake (HACU) process Nefiracetam – potentiates nicotinic acetylcholine receptors You should know that when a racetam affects ACh in some way, it usually means you need to make sure more ACh is available. Or the racetam will not be as effective. The other primary issue facing neurohackers are racetam-headaches. These headaches are unique because they usually only happen in a part of your brain. You’ll get to recognize them for what they are with more experience. Racetam-headaches are caused by using a racetam without enough supplemental choline. Your brain is telling you it’s starved for choline. So, while the concentrations in this product are relatively low (12mg Noopept), I find that it does have noticable benefits, especially taken 5 days on ad 2 days off. (ANY nootropic regime should have off days, never more than 2 weeks on) I would however recommend choline supplementation for any expectation of noticable benefit. Taking 3 or 4 "packets" of this product in a day (aside form the caffine) will absolutely give you a headache without taking additional choline. Personally, I like 30mg of noopept with huperzine a, centrophenoxine, choline and inositol once a day. For enhanced verbal fluidity, add Aniracetam (750mg), but be aware, this nootropic works on an inverted "U" curve...meaning too much and you lose the benefit, so never more than 1500mg within 8 hours, or things will get fuzzy.