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I've been taking this supplement for 10 days now. At first I took the required dose. I didn't get any benefit. Glucose was around 240mg/dl. So I took my meds that day. I decided to up the Berberine dose. I really have type 2. Metformin lowers insulin resistance but it also makes matters worse by storing the excess glucose in your liver and muscle tissue. The other med I take, glyburide, squeezes extra insulin out of your pancreas. Again making long term matters worse because your pancreas only makes so much insulin and then it's done. So I decided to increase the Berberine dosage with no meds. I posted a photo of my latest sensor scan. To get these results I take 4 capsules with every meal. I also eat ultra low carb. As an example yesterday I ate grilled scallops and sauteed spinach with garlic and parmesan cheese (I made it). Today will be a hamburger w/cheese (no bread) and a salad. No bread, no pasta, no corn, no potatoes. Just eating like this with no meds wasn't enough to keep my glucose under 200. I have not taken Metformin or Glyburide since August 12th. I am not a doctor but I am someone who took Bayetta, Januvia and was lucky enough to have horrible side effects and stopped using it. Bayetta caused pancreatitis and Januvia causes a hyperactive thyroid that took 1 year to clear up. I've been on Metformin since 2007 and Metformin + Glyburide since 2012. I've been looking for a natural treatment for T2 since I was initially diagnosed. I think I've found it. If you wear a glucose sensor like I do maybe you can try a similar dosage to what I am taking to verify my findings ? If someone is borderline diabetic I think the recommended dosage will work. But if someone had it for a while, has hit highs over 300mg/dl, without meds can easily hit 240, and has the discipline to stick to an ultra low carb diet, and a realtime glucose sensor like I do, try 4 capsules with each meal. It would be useful if we have several people here document my findings. I do not recommend taking more than the recommended dosage if you don't have a glucose monitor because low glucose is dangerous. As you can see from the reading I am not at a prediabetic level, but 157 from a non medicated regular > 260mg/dl is HUGE! I am hoping it will improve further over time. There are times that I do not drop below 160mg/dl when on Metformin and Glyburide. Berberine appears to be a promising oral treatment for T2.