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I started taking Neo40 this week and I am already seeing a difference in my blood pressure, starting pressure at 168/100 (while on prescription medication) to 138/90 after 5 days taking twice a day 12 hours apart (still taking my meds). According to instructions you need to do twice a day for the first 30-45 days. I am using this as a stop gap method to lower my blood pressure while I try to lose weight and it seems to be working. Once I take weight off I will re-evaluate the need. I should also mention that I do feel much better and have a bit more energy too, which is a plus. Thanks! Update... I had to stop taking because of water retension, which may not happen to everyone. Otherwise it was reducing my blood pressue.